加入收藏
百奥莱博公司客服电话百奥莱博QQ百奥莱博QQ百奥莱博QQ
百奥莱博公司微信服务号

产品目录

过氧化物酶标记GDF15抗体图片
产品货号:
Z16930
中文名称:
过氧化物酶标记GDF15抗体
英文名称:
Anti-GDF15 Antibody Peroxidase Conjugated
产品规格:
100μg
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-GDF15 Antibody Peroxidase Conjugated
指标别名GDF 15;GDF15;MIC 1;MIC1;NAG 1;NRG 1;NSAID activated gene 1 protein;NSAID regulated gene 1 protein;PDF;PLAB;Placental TGF beta;PTGFB
克隆性Polyclonal
检验物种human,mouse
应用范围ELISA
基因名称GDF15
抗体来源Rabbit
抗体类型IgG
免疫原Anti-NAG-1 (C-terminal specific) antibody was prepared by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminal end of human NAG-1 protein.?A residue of cysteine was added to facilitate coupling to KLH.
成分0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,10mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free,0.01% (w/v) Gentamicin Sulfate.Do NOT add Sodium Azide!
纯化方式Anti-NAG-1 (C-terminal specific) was affinity purified from monospecific antiserum by immunoaffinity chromatography.This antibody reacts with the C-terminus of endogenous NAG-1 protein from human and mouse tissues.A BLAST analysis suggests reactivity with NAG-1 from chimpanzee and macaque based on a 100% homology.Partial reactivity is expected against rat based on an 86% homology with the immunizing sequence.Cross-reactivity with NAG-1 from other sources has not been determined.
浓度1.07mg/mL by UV absorbance at 280nm
产品形态Lyophilized
保存条件Store vial at 4℃ prior to restoration.For extended storage aliquot contents and freeze at -20℃ or below.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.?Expiration date is one (1) year from date of opening.
背景资料Non-steroidal anti-inflammatory drug (NSAID) activated gene (NAG-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily.NAG-1 is also known as Macrophage Inhibitory Cytokine-1 (MIC-1),Growth Differentiation Factor 15 (GDF15),Placental Bone Morphogenetic Protein (PLAB),or Prostate Derived Factor (PDF).NAG-1 is expressed in human placenta,prostate and colon.It possesses antitumorigenic and proapoptotic activities.NAG-1 expression is dramatically increased in inflammation,injury and malignancy.Increase of NAG-1 expression is a feature of many cancers including breast,colon,pancreas and prostate.In a number of studies,NAG-1 expression was increased by a number of NSAIDs.This increase in expression may correlate with the chemopreventive effect NSAIDs seem to have with certain cancers.NAG-1 expression is also induced by PPAR gamma ligands and by several dietary compounds such as conjugated linoleic acids (CLAs),naturally occurring fatty acids in ruminant food products,indoles,epicatechin gallate,and genistein.Induced expression of NAG-1 results in stimulation of apoptosis and inhibition of cell growth.Inhibition of NAG-1 induced expression by small interference RNA (siRNA) results in repression of induced apoptosis.NAG-1 expression is regulated by a numbers of transcription factors such as ERG-1 and Sp1.EGR-1 may be necessary for NSAID-induced NAG-1 expression.The study of expression of NAG-1 proteins,including variants,is important to define their potential role as serum biomarkers for cancer diagnosis,treatment monitoring,epidemiology study,and nutrition surveys.
Uniprot IDQ99988
推荐稀释比ELISA:1:10,000-1:50,000
IHC:1:500~1:2,500
WB:1:1,000-1:5,000

相关搜索:过氧化物酶标记GDF15抗体GDF15多抗Anti-GDF15 Antibody Peroxidase Conjugated
首页 |  关于我们 |  联系我们 |  在线咨询 |  网站地图
北京百奥莱博科技有限公司 京ICP备14007103号-3